【临床病史】:患者,男性,52岁,出现多个非特异性的主诉,包括无力,关节疼痛和体重减轻。52-year-old male presented with multiple nonspecific complaints, including weakness, joint pains and weight loss。
【影像图片】MRI图像



【影像表现】:Figure 1 and Figure 2: Enhancing thickened pituitary infundibulum (circle in Figure 1). 图1、2显示强化的垂体漏斗(绿色环)



【影像诊断】:Lymphocytic hypophysitis 淋巴细胞性垂体炎
【诊断要点】:Rare cause of infundibular thickening 垂体漏斗增厚的少见原因
Most often in peripartum females 大多数见于围产期妇女
Usually present with hypopituitarism or symptoms of mass effect 通常表现为垂体机能减退症或肿块占位效应所致的症状
【讨论】:Lymphocytic hypophysitis is an inflammatory lesion of the pituitary gland characterized by lymphocytic infiltration. The disease was first recognized in 1962 by Goudie and Pinkerton. The disease is rare, with a striking female predominance (approximately 9:1). As of 1997, only six cases had been diagnosed in men; however, definitive diagnosis requires pathologic correlation either through surgery or autopsy. There is a predilection for the disease during pregnancy and the postpartum period.
淋巴细胞性垂体炎是以淋巴细胞浸润为特征的垂体炎性病变。本病最初是Goudie和Pinkerton在1962提出了的。这是一种少见的、主要以女性为主(大约9:1)的病变。1997年,仅有6例是发生在男性中,然而最终需要通过手术或尸检获得的病理来确诊。病变主要发生在妊娠和产后。
Radiologically, the disease is characterized by homogeneously enhancing pituitary mass with infundibular thickening. This is often difficult to distinguish from an atypically enhancing macroadenoma; however, the finding of dural enhancement or extrapituitary involvement within the subarachnoid space can favor the diagnosis of lymphocytic hypophysitis.
放射学上,病变的特征是明显均匀强化的垂体肿块伴有漏斗增厚。这通常与不典型强化的垂体巨腺瘤难以鉴别,然而,如果出现硬脑膜强化或垂体外蛛网膜下腔的累及,可以提示淋巴细胞性垂体炎。
Clinically patients present with either partial/total hypopituitarism or symptoms related to mass effect. Treatment consists of corticosteroids with replacement of any deficient hormones.
临床上病人表现为部分或完全的垂体机能减退症或肿块占位效应所致的症状。治疗包括皮质类固醇以及任何短缺的激素替代疗法。