【双语学影像】神经节胶质瘤恶变一例

Description

A 55-year-old woman with left-side weakness and progressive confusion

55岁女性,左侧肢体无力,意识模糊逐渐加重。

【双语学影像】神经节胶质瘤恶变一例

【双语学影像】神经节胶质瘤恶变一例

【双语学影像】神经节胶质瘤恶变一例

Legends


Noncontrast CT scan (A) demonstrates a heterogeneous lesion involving both the frontal lobes. Calcification is seen within this lesion. Axial T2WI (B) and contrast-enhanced sagittal T1WI (C) demonstrate a heterogeneously enhancing lesion involving both frontal lobes and extending across the anterior body of the corpus callosum. Axial DSC-perfusion MRI (D) demonstrates increased perfusion from the lesion. H&E stain (E) confirms the diagnosis . Malignant transformation was seen on pathology.

CT平扫示双侧额叶可见不均质肿块,内可见钙化。

横断位T2WI及矢状位增强T1WI示病灶通过胼胝体前部跨越中心累及双侧额叶,增强扫描肿块不均匀强化。

横断位动态磁敏感对比增强(dynamic susceptibility weighted contrast enhanced,DSC)灌注加权像示病灶内灌注增加。【双语学影像】神经节胶质瘤恶变一例

H&E stain (E) confirms the diagnosis . Malignant transformation was seen on pathology.

H&E染色证实神经节胶质瘤诊断,并可见恶变征象。

【双语学影像】神经节胶质瘤恶变一例

Ganglioglioma with Malignant Transformation

神经节胶质瘤恶变


  • Gangliogliomas are glioneuronal tumors of central nervous system, affecting mainly children and young adults. Malignant transformation is rarely seen.

    神经节胶质瘤是来源于中枢神经系统神经胶质的一类肿瘤,常累及儿童和青少年,恶变罕见。

  • Clinical Presentation: Chronic epilepsy refractory to medication.

    临床表现:长期癫痫,药物治疗效果不佳。

Key Diagnostic Features

  • Common location: Cortical superficial location within the cerebral hemispheres, predilection for the frontal and temporal lobes. Other uncommon sites are reported.

    好发部位:大脑半球皮层区,特别是额叶和颞叶。其他少见部位也有报道。

  • The classic appearance of ganglioglioma is a cystic lesion with a solid enhancing mural nodule, often calcified. “Bizarre” patterns of calcification can be seen.

    神经节胶质瘤典型表现为囊性病变伴实性壁结节,常可见钙化,钙化形态不规则。

DDx

  • Pleomorphic xanthoastrocytoma

    多形性黄色星形细胞瘤

  • Pilocytic astrocytoma

    纤维性星形细胞瘤

  • Oligodendroglioma

    少突胶质细胞瘤

Rx

Surgical resection

手术切除

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